Xenotransplantation moratorium

Harmful moratorium on stem cell research.

Clinical xenotransplantation.

Two baboon liver xenografts transplanted to patients with B virus hepatitis supported life for 70 and 26 days but did not function optimally despite minimum or no histopathologic findings of overt humoral or cellular rejection in serial biopsies. However, there was evidence of complement activation in both cases, which in retrospect was thought to explain the unsatisfactory outcome. Strategies ...

Liver xenotransplantation.

During the past 30 years orthotopic liver transplantation has become a highly successful form of surgical treatments. The significant advances achieved in this field have led to an increased demand for organs and created a wide gap between organ availability and organ supply. A wider availability of organs for transplantation would allow an expansions rather than a contraction of the indication...

Proposed Moratorium on Changes to Network Protocol

Bill Crowther’s RFC No. 67 raised a much more fundamental issue than the question of marking. Any change to presently established protocol is going to involve changes in the hardware/software development efforts that have, in some instances, been going on for over 6 months. In the case of Multics, this effort has yielded programs either complete or in the advanced debugging stages. This is no d...

Kidney Xenotransplantation

Xenotransplantation using pigs as donors offers the possibility of eliminating the chronic shortage of donor kidneys, but there are several obstacles to be overcome before this goal can be achieved. Preclinical studies have shown that, while porcine renal xenografts are broadly compatible physiologically, they provoke a complex rejection process involving preformed and elicited antibodies, heig...